Senior Research Associate, Chemistry R&D

Company Overview

Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights.

We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications.

At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality.

About The Job

The Chemistry R&D Senior Research Associate will execute the synthesis, purification, characterization, and QC analysis of novel modified nucleoside/nucleotide motifs that are needed for broader R&D efforts within the organization. This role requires hands-on experience in an industrial organic chemistry lab setting, and the chemist should be comfortable working with sensitive compounds and complex purification and QC analysis techniques. This chemist will contribute to development of crucial upstream materials that will pillar the core technology at Sarmal.

Key Responsibilities

Synthesize modified nucleosides/nucleotides using a variety of synthesis techniques. Purify reaction products using preparative HPLC, flash chromatography, and other appropriate purification methods. Characterize compounds using analytical techniques including LC-MS, NMR, IR, UV/Vis, TLC, and related methods. Optimize reaction conditions and develop analytical methods to produce high-quality compounds that meet project requirements. Maintain accurate and detailed electronic laboratory notebooks and manage inventory of synthesized compounds and related materials. Operate, maintain, and troubleshoot laboratory equipment and analytical instrumentation. Analyze and interpret experimental data and present findings at project and departmental meetings.

Qualifications

Strong understanding of modern organic chemistry techniques in literature and in laboratory. Hands-on experience organic chemistry synthesis techniques including air- and moisture-sensitive reactions using Schlenk techniques and inert atmosphere conditions. Proficiency in operating analytical instrumentation such as HPLC and LC-MS with the ability to interpret results from data acquisition. Strong analytical chemistry skills using LC-MS, NMR, IR, UV/Vis, TLC, and related techniques. Experience in chemoenzymatic reactions is a plus. Strong documentation and scientific communication skills. Strong sense of teamwork, flexibility, and enthusiasm for advancing new technologies.

Education

B.S. or M.S. in organic chemistry, nucleotide/nucleic acid chemistry, bioorganic chemistry, or related discipline. 5–8 years post-B.S. or 2-4 years post-M.S. of relevant industry experience in organic chemistry, nucleic acid chemistry, medicinal chemistry, or related fields.

Benefits & Perks

Sarmal offers a competitive and comprehensive benefits package, including:

Medical, dental, and vision coverageCompany-paid life insurance401(k) retirement planGenerous paid time offAccess to additional voluntary benefits, employee perks, and discount programsWe are committed to supporting the well-being of our employees and providing a strong foundation for both professional and personal success.

$72,000 - $85,000 a year

California Pay Transparency Statement.

The anticipated salary range for this position is $72,000 – $85,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations.

EEO Statement

Sarmal is an equal opportunity employer committed to building a diverse and inclusive workplace. We do not discriminate based on race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran status, or any other characteristic protected by applicable federal, state, or local laws.

Reasonable Accommodation Statement

Sarmal is an equal opportunity employer that values diversity and inclusion. We welcome applicants of all backgrounds and consider all qualified candidates in accordance with applicable laws.

Why Join Sarmal

Work on cutting-edge genomics and molecular detection technologiesCollaborate with a deeply technical, cross-functional teamContribute to foundational platform development at an early stageHave visibility into and impact on core technical and strategic decisionsHelp shape the infrastructure, culture, and future direction of the company

Closing Statement

Join us in advancing the next generation of genomic technologies and shaping the future of precision health.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.