Principal Scientist, ADC Pharmacology

About the role

At Callio, we're building dual-payload ADCs designed to block cancer's escape routes, with our HER2-targeted dual-payload ADC already in the clinic and a growing pipeline behind it.

Tasks

• Help set and drive pharmacology strategy across multiple dual-payload programs
• Spend ~25–50% of your time at the bench on in vitro/ex vivo ADC characterization and payload MOA studies
• Lead external studies, managing CROs (particularly in Asia), vendors, and collaborators
• Act as the research expert on cross-functional teams spanning Seattle, San Diego, and Singapore

Requirements

• PhD in pharmacology, cell biology, cancer biology, or related field with 5+ years industry experience (or MS with 8+ years)
• Hands-on discovery ADC experience; novel payload work is a big plus
• Expertise in cytotoxicity, internalization, bystander killing, and linker stability assays, plus familiarity with in vivo and NHP tox/TK study design
• A self-starter who loves the balance of strategy and execution in a lean startup

How to apply

• Send your resume with the job title in the subject line.

Location

• Seattle